卫青

职称：教授

研究方向：利用线虫、果蝇、小鼠等多种模式研究纤毛和精子鞭毛的发生机制及相关疾病机理

通讯地址：qwei@sxu.edu.cn

卫青，1980年生，山西大学教授，博士生导师。2002年本科毕业于山西大学生命科学学院。2008年博士毕业于中国科学院上海生命科学研究院植物生理生态研究所。2008 -2015年于美国梅奥医院（Mayo Clinic）从事博士后研究。2015年8月加入中国科学院上海生命科学研究院植物生理生态研究所任研究员。2016年入选第十二批国家“青年**”。2019年3月加入中科院深圳先进技术研究院，获深圳市“孔雀计划”海外高层次B类人才。2024年3月入职山西大学。主要利用线虫、果蝇、小鼠等多种模式研究纤毛和精子鞭毛的发生机制及相关疾病机理。先后主持国家自然科学基金面上项目3项，深圳市面上项目1项。研究成果以第一作者或通讯作者在Nature Cell Biology, Nature Communications（4篇）, Advanced Science，Current Biology，PLOS Biology（2篇）等国际著名期刊上发表。

教育和工作经历

2024/03 — 至今：山西大学合成生物学学院，教授

2019/03 — 2024/02：中国科学院深圳先进技术研究院生物医药与技术研究所，研究员

2015/08 — 2019/02：中国科学院上海生命科学研究院植物生理生态研究所，研究员

2013/06 — 2015/08：美国梅奥医院（Mayo Clinic），Research Associate

2008/06 — 2013/06：美国梅奥医院（Mayo Clinic），Research Fellow

2002/09 — 2008/06：中国科学院上海生命科学研究院植物生理生态研究所，植物学专业，博士

1998/09 — 2002/07：山西大学生命科学学院，生物化学专业，学士

近年来主持和参与的科研项目 

1. 主持：深圳市基础研究面上项目，JCYJ20230807140805011，初级纤毛在小鼠卵巢发育和功能中的作用及机制研究， 2024/01-2026/12, 30万

2. 主持：国家自然科学基金面上项目，32070692，CEP290在纤毛发生起始过程中的作用及机制研究，2021/01-2024/12，58万

3. 主持：国家自然科学基金面上项目，31871357，以果蝇为模式研究纤毛过渡纤维（Transition fibers）的形成和功能，2019/01-2022/12，60万

4. 主持：国家自然科学基金面上项目，31671549，纤毛病蛋白HYLS1调控纤毛发生的分子机理，2017/01-2020/12， 60万

5. 主持：**青年项目，2016-2018，200万

6. 主持：国家人社部“2016年度留学人员科技活动项目择优资助”(启动类)，3万

代表性论文

1. Chen H.#, Wu Z.#, Yan Z.#, Chen C., Zhang Y., Wang Q., Gao Y., Ling K., Hu J., Wei Q*. The ARPKD Protein DZIP1L Regulates Ciliary Protein Entry by Modulating the Architecture and Function of Ciliary Transition Fibers. Advanced Science 2024 Apr 17:e2308820. doi: 10.1002/advs.202308820.

2. Wu Z.#, Chen H.#, Zhang Y.#, Wang Y., Wang Q., Augière C., Hou Y., Fu Y., Peng Y., Durand B.*, Wei Q.* Cep131-Cep162 and Cby-Fam92 complexes cooperatively maintain Cep290 at the basal body and contribute to ciliogenesis initiation. PLOS Biology 2024 Mar 5; 22(3):e3002330. doi: 10.1371/journal.pbio.3002330.

3. Ma X., Zhang Y., Zhang Y., Zhang X., Huang Y., He K., Chen C., Hao J., Zhao D., LeBrasseur N., Chini E., Wei Q.*, Ling Q.*, Hu J*. A stress-induced cilium-to-PML-NB route drives senescence initiation. Nature Communications 2023, 14: 1840.

4. Hou Y, Zheng S, Wu Z, Augière C, Morel V, Cortier E, Duteyrat JL, Zhang Y, Chen H, Peng Y, Durand B*, Wei Q.* Drosophila transition fibers are essential for IFT-dependent ciliary elongation but not basal body docking and ciliary budding. Current Biology. 2023 Jan 11:S0960-9822(22)01983-2.

5. Hou Y., Wu Z., Wei Q.* Alström Syndrome protein Alms1 is required for maintaining meiotic centriole engagement in spermatocytes of Drosophila. BioRxiv doi: https://doi.org/10.1101/2023.09.12.557481

6. Wang Q., Wu Z., Wan D. *, Wei Q.* The Molecular Mechanism underlying the Initiation of Primary Cilia Biogenesis. Chinese Journal of Cell Biology 2023, 45(11): 1731–1744.

7. Hou YN, Zhang YY, Wang YR, Wu ZM, Luan YX, Wei Q. IFT52 plays an essential role in sensory cilia formation and neuronal sensory function in Drosophila. Insect Science 2022 Nov 3. doi: 10.1111/1744-7917.13140

8. Hong H.#, Chen H.#, Zhang Y., Wu Z., Zhang Y., Zhang Y., Hu Z., Zhang J., Lin K., Hu J., Wei Q.* DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans. PLOS Genetics 2021, 17(6): e1009618.

9. Yan H.#, Chen C.#, Chen H., Hong H., Yan H., Ling K., Hu J.*, Wei Q.* TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating. Nature Communications 2020, 11(1):2196.

10. Wu Z., Pang N., Zhang Y., Chen H., Peng Y., Fu J., Wei Q.* CEP290 is essential for the initiation of ciliary transition zone assembly. PLOS Biology 2020, 18(12): e3001034.

11. Hou Y., Wu Z., Zhang Y., Chen H., Hu J., Guo Y., Peng Y. and Wei Q.* Functional analysis of hydrolethalus syndrome protein HYLS1 in ciliogenesis and spermatogenesis in Drosophila. Frontiers in Cell and Developmental Biology 2020, 8:301.

12. Wei Q.#*, Zhang Y.#, Schouteden C., Zhang Y., Zhang Q., Dong J., Wonesch V., Ling K., Dammermann A.*, Hu J.* The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate. Nature Communications 2016, 7:12437.

13. Wei Q., Ling K. and Hu J. The essential roles of transition fibers in the context of cilia. Current Opinion in Cell Biology 2015, 35: 98-105.

14. Wei Q., Xu Q., Zhang Y., Li Y., Zhang Q., Hu Z., Harris P.C., Torres V.E., Ling K. and Hu J. Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes. Nature Communications 2013, 4: 2750.

15. Wei Q.#, Zhang Y.#, Li Y., Zhang Q., Ling K. and Hu J. The BBSome controls IFT assembly and turnaround in cilia. Nature Cell Biology 2012, 14(9): 950-957.

16. Zhang L.#, Wei Q.#, Wu W.#, Cheng Y, Hu G, Hu F, Sun Y, Zhu Y, Sakamoto W, Huang J. Activation of the heterotrimeric G-protein alpha-subunit GPA1 suppresses the ftsh-mediated inhibition of Chloroplast Development in Arabidopsis. The Plant Journal 2009, 58(6): 1401-1453.

17. Wei Q., Zhou W., Hu G., Wei J., Yang H. and Huang J. Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls. Cell Research 2008, 18: 949-960.

18. Wu W.#, Elsheery N.#, Wei Q.#, Zhang L. and Huang J. Defective etioplasts observed in variegation mutants may reveal the light-independent regulation of white/yellow sectors of Arabidopsis leaves. Journal of Integrative Plant Biology 2011, 53(11): 846-857.

19. Wei Q., Xiong Y., Luan Y., Yang Y., Xie R. and Yin W. First Note on Chromosomes and Male Meiosis Division of Collembolan in China. Zoological Research 2005, 26(1):96-100.

20. Zhang Y, Hao J, Tarrago MG, Warner GM, Giorgadze N, Wei Q, Huang Y, He K, Chen C, Peclat TR, White TA, Ling K, Tchkonia T, Kirkland JL, Chini EN, Hu J. FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue. Cell Rep. 2021 Aug 3;36(5):109481.

21. Lin W., Qiao C., Hu J., Wei Q., Xu T., Conserved role of ATP synthase in mammalian cilia. Experimental Cell Research 2021, 401(1): 112520.

22. Luan W., Hao C., Li J., Wei Q., Gong J., Qiu Y., Lu Y., Shen C., Xia Q., Xie X., Zhang Mei., Abuduxikuer K., Li Z., Wang L., Xing Q., Knisely A., Wang J. Biallelic loss-of-function ZFYVE19 mutations are associated with congenital hepatic fibrosis, sclerosing cholangiopathy and high-GGT cholestasis. Journal of Medical Genetics 2020, doi: 10.1136/jmedgenet-2019-106706.

23. Zhang J., Xue X., Qiao Y., Li D., Wei Q., Zhang F., Qin X. Astragaloside IV Extends Lifespan of Caenorhabditis elegans by Improving Age-Related Functional Declines and Triggering Antioxidant Responses. Rejuvenation Research 2020, doi: 10.1089/rej.2020.2312.

24. Xu Q., Zhang Y., Wei Q., Huang Y., Hu J. and Ling K. Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis. Nature Communications 2016, 7:10777.

25. Xu Q., Zhang Y., Wei Q., Huang Y., Li Y., Ling K. and Hu J. BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors. Scientific Reports 2015, 5: 11855. 

26. Li Y., Zhang Q., Wei Q., Zhang Y., Ling K. and Hu J. SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors. Journal of Cell Biology 2012, 199(4): 589-598.

27. Li Y., Wei Q., Zhang Y., Ling K. and Hu J. Small GTPases ARL-13 and ARL-3 coordinate the IFT integrity in cilia. Journal of Cell Biology 2010, 189(6): 1039-1051.