郭一鸣

职称：校聘副研究员

研究方向：新酶发掘（Genome Mining），酶的催化机理；酶分子工程（理性设计，定向进化，计算机辅助模拟设计）；采用级联反应等策略来高效制备木质

                 素衍生高附加值化合物

通讯地址：yiming.guo@sxu.edu.cn

郭一鸣，男，博士，山西大学合成生物学学院，校聘副研究员。2023年5月于荷兰格罗宁根大学（University of Groningen, Netherlands）获得理学博士学位。先后参与国家科技重大专项（转基因生物新品种培育转基因水稻新品种培育）子课题-新型草甘膦降解型基因的体外验证及定向进化，参与欧盟项目SMARTBOX。以独立一作身份在Nature Communications, ACS Catalysis, Adavanced Synthesis & Catalysis发表研究论文3篇，在其它高水平期刊合作发表论文5篇，一项科技成果已经进入企业中试阶段。

教育背景及工作经历：

2023.07 – 至今          山西大学合成生物学院 校聘副研究员

2018.10 – 2023.05    荷兰格罗宁根大学 博士

2018.06 – 2018.08    捷克国家科学院—有机化学和生物化学所 科研助理

2011.09 – 2017.06    武汉华中农业大学 本硕连读（国家应用生物技术基地班）

科研项目：

1.国家科技重大专项（转基因生物新品种培育转基因水稻新品种培育）子课题-新型草甘膦降解型基因的体外验证及定向进化（参与）

2.欧盟SMARTBOX项目（参与）

代表性论文

1. Yiming Guo, Laura Alvigini, Milos Trajkovic, Lur Alonso-Cotchico, Emanuele Monza, Simone Savino, Ivana Marić, Andrea Mattevi & Marco W. Fraaije. Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound. Nat. Commun. 13, 7195 (2022).

2. Yiming Guo, Laura Alvigini, Mohammad Saifuddin, Ben Ashley, Milos Trajkovic, Lur Alonso-Cotchico, Andrea Mattevi, and Marco W. Fraaije. One-pot biocatalytic synthesis of rac-syringaresinol from a lignin-derived phenol.  ACS Catal. 13, 14639–1464 (2023)

3. Ivana Marić, Yiming Guo, Maximilian J. L. J. Fürst, Korneel Van Aelst, Sander Van den Bosch, Mario De Simone, Lígia O. Martins, Bert F. Sels, Marco W. Fraaije. A one-pot, whole-cell biocatalysis approach for vanillin production using lignin oil. Adv. Synth. Catal. (2023)

4. Laura Alvigini, Alejandro Gran-Scheuch, Yiming Guo, Milos Trajkovic, Mohammad Saifuddin, Marco W Fraaije, Andrea Mattevi. Discovery, Biocatalytic Exploration and Structural Analysis of a 4-Ethylphenol Oxidase from Gulosibacter chungangensis. ChemBioChem (2021)

5. Yuqing Qin, Gaobing Wu, Yiming Guo, Da Ke, Jiakang Yin, Donglin Wang, Xuezhu Fan, Ziduo Liu, Lifang Ruan, Yonggang Hu. Engineered glyphosate oxidase coupled to spore-based chemiluminescence system for glyphosate detection. Anal. Chim. Acta. (2020)

6. Gaobing Wu, Tao Zhan, Yiming Guo, Ashok Kumar, Ziduo Liu. Asn336 is involved in the substrate affinity of glycine oxidase from Bacillus cereus. Electron. J. Biotechnol. (2016)

7. Shaohui Yuan, Wei Jiang, Lin Chen, Yiming Guo, Ziduo Liu. A novel serine hydroxymethyltransferase from marine bacterium Alcanivorax sp. and its application on enzymatic synthesis of L-serine. J. Mol. Catal., B Enzym. (2014)

8. Kai Zhang, Yiming Guo, Pei Yao, Yongjun Lin, Ashok Kumar, Ziduo Liu, Gaobing Wu, Lili Zhang. Characterization and directed evolution of BliGO, a novel glycine oxidase from Bacillus licheniformis. Enzyme Microb. Technol. (2016)